kit ligand การใช้

• CD117 is a receptor tyrosine kinase type III, which binds to stem cell factor ( a substance that causes certain types of cells to grow ), also known as " steel factor " or " c-kit ligand ".
• PCP-2 and the c-Kit tyrosine kinase receptor interact constitutively in these cells, and PCP-2 was shown to be tyrosine phosphorylated upon stimulation with the c-Kit ligand, SCF . Antisense oligonucleotide treatment of megakaryocyte cells to reduce PCP-2 protein expression resulted in a significant reduction in megakaryocyte progenitor proliferation.